Time courses of urinary creatinine excretion, measured creatinine clearance and estimated glomerular filtration rate over 30 days of ICU admission

Baseline urinary creatinine excretion (UCE) is associated with ICU outcome, but its time course not known. We determined changes in UCE, plasma creatinine, measured clearance (mCC) and estimated glomerular filtration (eGFR) patients an ICU-stay ?30d without acute kidney injury stage 3. The Cockcroft-Gault, MDRD (modification of diet renal disease) CKD-EPI (chronic disease epidemiology collaboration) equations were used. In 248 5143 UCEs hospital mortality was 24%. Over 30d, UCE absolutely decreased male survivors non-survivors female nonsurvivors by 0.19, 0.16, 0.10 0.05 mmol/d/d (all P < 0.001). Relative decreases similar all four groups: 1.3, 1.4, 1.2 0.9%/d respectively. mCC remained unchanged, eGFR rose 31% (CKD-EPI) 73% (MDRD) Cockcroft-Gault 59% 1 month stay, declined ?1%/d which may correspond to equivalent decline muscle mass. These rates decrease survivors, non-survivors, males females underscoring the intransigent nature this process. contrast clearance, estimates progressively during stay.